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Orthox was founded in 2008 by life scientist, Dr Nick Skaer, and knee surgeon, Professor Oliver Kessler, to exploit the potential of silk technology developed at at Oxford University by Professor Fritz Vollrath’s Oxford Silk Group in the Department of Zoology. Together with Dr David Knight, Professor Vollrath founded Oxford Biomaterials Ltd to develop and exploit the properties of natural silks for medical applications. The technology they developed was spun out through Isis Innovations, into Spinox Ltd. in 2002 which later became Oxford Biomaterials Ltd. in 2004. As Chief Scientist and then CEO of Oxford Biomaterials, Dr Skaer co-invented and developed the FibroFix:tm: technology platform over the subsequent four years before securing the exclusive licenses from Oxford Biomaterials to exploit FibroFix:tm: in the field of cartilage and bone repair.

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